منابع مشابه
Statin-Related Muscle Toxicity
yperlipidemia is widely recognized as one of the major risk factors for coronary heart disease (CHD). Whereas therapeutic lifestyle changes are the first-line modality for reducing low-density lipoprotein (LDL) cholesterol, many patients also require medication to achieve cholesterol level goals. Primary and secondary prevention studies have demonstrated that adequate reduction of LDL cholester...
متن کاملScreening for statin-related toxicity: the yield of transaminase and creatine kinase measurements in a primary care setting.
BACKGROUND Recommendations for monitoring levels of transaminases (alanine aminotransferase and aspartate aminotransferase) and of creatine kinase (CK) in patients taking 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) vary and are not based on data from clinical practice. We performed a study to determine the yield of routine screening of aminotransferase and CK levels amo...
متن کاملTransporter pharmacogenetics and statin toxicity.
Polymorphisms in transporter genes can have profound effects on statin pharmacokinetics. In particular, a common genetic variant of organic anion-transporting polypeptide 1B1 reduces the hepatic uptake of many statins, increasing the risk of statin-induced myopathy. Similarly, genetically impaired adenosine triphosphate (ATP)-binding cassette G2 transporter efflux activity results in a marked i...
متن کاملStatin-related myotoxicity.
Statin therapy has a very important role in decreasing cardiovascular risk, and treatment non-compliance may therefore be a concern in high cardiovascular risk patients. Myotoxicity is a frequent side effect of statin therapy and one of the main causes of statin discontinuation, which limits effective treatment of patients at risk of or with cardiovascular disease. Because of the high proportio...
متن کاملStatin Muscle Toxicity and Genetic Risk Factors
In the context of statin monotherapy, the frequency of myopathy is ~1/1,000, and the frequency of rhabdomyolysis is ~1/100,000. The frequency increases with dose [7,8]. Clinicians often measure serum CK levels, as parameter of severity, but the correlation between symptoms and CK level is incomplete. Therefore, the clinical interpretation of CK level is complex. Elevations less than three-fold ...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 2003
ISSN: 0003-9926
DOI: 10.1001/archinte.163.6.688